Header Logo
Keywords
Last Name
Institution
Announcement

You can now add alternative names! Click here to add other names that you've published under.
Back to Search Results

Connection

Search Results to Thomas Kelly Jr

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Kelly Jr, Thomas

PropertyValue
overview We are defining the mechanisms of cross-talk between activated fibroblasts and tumor associated macrophages that results in facilitation of breast cancer growth and progression that ultimately kills people with breast cancer. Specifically, we are investigating if activated fibroblasts are capable of converting immune activating macrophages (M1) to immune suppressive macrophages (M2). We are also investigating if immune suppressive macrophages can cause fibroblast activation. Steven R. Post and I have shown that SR-A mediated adhesion of macrophages to modified collagen results in PGE2 production and this PGE2 feeds back onto the macrophages and modulates cytokine production towards an M2 phenotype as evidenced by decreased TNF-alpha and increased IL-10 production (Nikolic et al, 2015, J. Leukocyte Biol. Feb 25. pii: jlb.2A1014-471RR. [Epub ahead of print]). We are currently looking to determine if adhesion of macrophages to FAP-modified collagen also promotes the M2 phenotype. I am an experienced PI with a broad background in cellular biology, and since 1992, I have focused my research on two matrix degrading enzymes—fibroblast activation protein-a (FAP) and heparanase—and their relationship to breast cancer. For over 20 years, I have led an independent research group that studies mechanisms of breast cancer metastasis that has been continuously funded by DoD-BCRP, NIH, and Industry grants and contracts. As a result, I am experienced in successfully administering research projects (e.g., staffing, research protections and budget) and collaborating with both basic and clinical scientists. My research has been published in prestigious cancer journals, such as Cancer Research and Blood. Through this research, my team and I have developed extensive experience with FAP biology in breast cancer.

One or more keywords matched the following items that are connected to Kelly Jr, Thomas

Item TypeName
Academic Article Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.
Academic Article Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.
Academic Article Heparanase promotes the spontaneous metastasis of myeloma cells to bone.
Academic Article Deficiency in surface expression of E-selectin ligand promotes lung colonization in a mouse model of breast cancer.
Academic Article Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.
Academic Article In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells.
Academic Article The utility of PAX-2 and renal cell carcinoma marker immunohistochemistry in distinguishing papillary renal cell carcinoma from nonrenal cell neoplasms with papillary features.
Academic Article Seprase, a membrane-bound protease, is overexpressed by invasive ductal carcinoma cells of human breast cancers.
Concept Neoplasm Metastasis
Concept Lymphatic Metastasis
Academic Article A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva.
Academic Article Fibroblast activation protein-a promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions.
Academic Article Evaluation of seprase activity.
Academic Article Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases.
Academic Article Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells.
Academic Article Seprase complexes in cellular invasiveness.
Grant In vivo molecular laser detection and treatment of circulating cancer stem cells
Grant Photoswitchable nanoprobes for in vivo flow cytometry
Grant Lymph liquid biopsy in cancer
Grant Role of heparanase in osteolytic bone metastasis
Grant Fibroblast activation protein-alpha, a serine protease that facilitates metastasis by modification of diverse microenvironments
Grant Fibroblast activation protein-alpha, a serine protease that facilitates metastasis by modification of diverse microenvironments
Grant In vivo, noninvasive, ultrasensitive photoacoustic detection of early breast cancer metastasis in bone

Search Criteria
  • Neoplasm Metastasis